Natural Cycle IVF for PCOS Patients: Clomid Failed but Metformin with NCIVF Worked

Most patients who have PCOS do not have regular menstrual cycles and therefore they cannot be treated with Natural Cycle IVF (NCIVF) as it requires patients to have fairly regular menstrual cycles.  This is an example of an interesting patient of mine who had irregular menstrual cycles, which upon taking Metformin became regular, thus allowing her to be successfully treated with NCIVF.


 A.H. is a 34 year old female who came to see me for a consultation in June, 2010.  She had never been pregnant after using no contraception for about 2 years.  Her infertility was directly related to her PCOS.  At another clinic she was first placed on Clomid 50mg for one cycle but she experienced severe headaches necessitating her to visit the ER for evaluation.  Her husband’s sperm were normal and her tubes open.  So, I suggested that she simply try Metformin with coitus for a few months but this did not result in pregnancy.  Interestingly, her menses became much more regular, occurring now about every 40-45 days.  About 50% of patients that I place on Metformin will develop regular menstrual cycles and many will spontaneously get pregnant without any other therapy.  But unfortunately, this did not happen for A.H.  So, she desired to try NCIVF.


In November, 2011, we transferred a single blastocyst embryo and she became pregnant in her first treatment cycle of NCIVF.  She is now 8 weeks pregnant and I have referred her back to her Obstetrician.  She took no Clomid or any other ovarian stimulation drugs, just Metformin which helped in making her ovulation and menstrual cycles more normal allowing her to undergo treatment with NCIVF. 


Now, we perform NCIVF in almost all patients with infertility as long as their menstrual cycles are fairly regular.  Although the use of Metformin in PCOS patients may be somewhat controversial, we have experienced amazing success  with many of our PCOS patients whom we simply place on Metformin alone and they achieve a spontaneous pregnancy.  When pregnancy does not occur, we find that many will begin to experience regular menstrual cycles and this allows us an opportunity to try NCIVF.  So, yes, NCIVF can be performed in those patients with PCOS who have regular or mildly irregular cycles.   


This January, we look forward to beginning our 6th year of performing NCIVF!  Dr. D   


Views: 566

Tags: DiMattina, M.D., Michael


You need to be a member of Fertile Grounds | IVF Forum | Tips for getting Pregnant to add comments!

Join Fertile Grounds | IVF Forum | Tips for getting Pregnant



  • Add Photos
  • View All

Latest Activity

Anonymous posted a discussion

Anyone Had Success With Own Eggs at Later Age?

Has anyone out here been successful using own eggs at later age in life (after 47)? See More
16 hours ago
Robin Webb R.N. replied to MindyK's discussion Just Starting Out
"    Hi Karen,           PCOS can be frustrating, but it's great that letrozole worked for ovulation so you're on the right path to a BFP!  Keep us posted on your cycle :)"
21 hours ago
Robin Webb R.N. replied to MindyK's discussion It finally happened! We are pregnant!
"Congratulations and thanks for sharing your story."
21 hours ago
Karen replied to MindyK's discussion Just Starting Out
"MindyK, Congratulations! I hope you have an easy pregnancy. I am staying positive and hoping that the second round takes. My take away from the last cycle is that the letrozole worked and that I am one step closer to pregnancy. Karen"
MindyK posted a discussion

It finally happened! We are pregnant!

I posted my first entry on this site sometime around October or November of 2014, and I want to share my experience with everyone in hopes to offer some encouragement.My husband and I came to DF after three years trying to conceive. I have PCOS and was told by my GYN that I would either never have children or it would be incredibly difficult to get pregnant. We saw Dr. Payson for the initial consult in October, and after the initial testing, we came back for a follow-up on 11/6/14. Everything…See More
MindyK replied to MindyK's discussion Just Starting Out
"Hi, Karen!  We decided to go with the Femara (Letrozole) and HCG trigger with timed intercourse back in November. After one round of the Femara and trigger shot, I am pregnant! I am 12 weeks now! Please stay positive! I know first time…"
Karen posted a discussion

PCOS and timed intco

Hello,I am trying to find other people in similar positions as me to share my thoughts, emotions, and experiences with. I am thinking that I am not the only one out that there that is going through this and that I am not the only one that could use to meet other people in the same boat.Here is my story:I have PCOS and I was diagnosed in April 2014. I had no idea that I had it. I was on birth control for many years and when I stopped the birth control I did not get my period. I went to my gyno…See More
Karen replied to MindyK's discussion Just Starting Out
"Hello, I have read this chain of postings and decided to respond since my situation is similar. I also have PCOS and tried 2 rounds of clomid with my gyno and I did not ovulate. I started with Dominion Fertility in September with Dr. Gordon. Based…"
Dominion Fertility's 2 blog posts were featured
Profile IconDalton Cary, FRANK KWABENA, Anonymous and 3 more joined Fertile Grounds | IVF Forum | Tips for getting Pregnant
Dr. Andrea Reh replied to Babywuensche's discussion When to try for second Ivf baby
"Hello! Welcome to Fertile Grounds and thank you for your post.  Congratulations on your baby!  What an exciting time, and I am sure you are enjoying your little one.  There are several factors to consider when trying for your second…"
Karen updated their profile
Jan 21
Dominion Fertility posted a blog post
Jan 21
Babywuensche posted a discussion

When to try for second Ivf baby

I conceived a child through ncivf at dominion and am interested in when would be a good amount of time before trying for a second one. We know we will need to do IVF again and I'm unsure how that affects timing- does it? I also had a c-section- does that affect when to do another Ivf cycle? Also is breastfeeding a problem? I got my cycle back after two months and my baby is now twelve months old. Is it okay to do Ivf while breastfeeding? What about only minimal breastfeeding when the baby is…See More
Jan 15
DinoS jone is now a member of Fertile Grounds | IVF Forum | Tips for getting Pregnant
Jan 14
Dominion Fertility posted a blog post

Going a little batty at Dominion Fertility.....

Monday, January 12, 2015Going a little batty at Dominion Fertility.....Last month I turned 51. I guess that turning 51 "beats the alternative" as my Nana used to say but the passage of…See More
Jan 14

Health Matters: Fertility and In Vitro Fertilization (IVF)

Follow Us


Enter your email address:

© 2015   Created by Dominion Fertility.

Badges  |  Report an Issue  |  Terms of Service